Venus is a Commander of Team Galactic, recruited after she had a major breakthrough at a pretty young age, although the research team she was part of hid that it was her who got it. Team Galactic catches wind and recruits her and she joins, interested in the idea of seeing a new universe created but unaware of the fatal consequences it could have.

Her signature mon is a shiny Sneasel which she rescued at a young age and the two are completely inseparable (quite literally they never go anywhere without each other). Though she's also seen with her beloved Mightyena a lot.

Unfortunately Team Galactic keeps her in the dark about how it'll harm the Lake Guardians and Dialga and Palkia as well as the fact that it'll destroy the old universe. She isn't even aware of the violence behind the scenes, only knowing about theft and property damage (which she excuses as necessary sacrifices for research). Eventually she witnesses Team Galactic getting violent and her doubts start, until she finally discovers a ruin that was hidden from her, talking all about the fatal consequences.

This part of her story follows the anime events pretty closely, just with her inserted. She decides to leave it up to the kids to save them, not finding it right to take the "hero"-spotlight with what she's been supporting but has arranged a backup-plan that will enable if they aren't fast enough and will only open a portal to the distortion world and keep damage in the Sinnoh region at a minimum. Her plan doesn't need to act but Cyrus gets trapped in the distortion world. Venus manages to flee, barely losing Looker and eventually catching a Sharpedo that takes her to the Hoenn region.